HCMV US28 Antibodies

Target Information

HCMV US28 is a viral chemokine receptor encoded by the Human Cytomegalovirus (HCMV) classified among the seven-transmembrane G-protein-coupled receptors with constitutive ligand-independent signaling activity. This receptor is known for its ability to bind a broad range of chemokines including both CC and CX_3C motifs facilitating viral immune evasion and cell-cell adhesion processes. US28 plays a significant role in HCMV pathogenesis contributing to viral persistence and influencing the transcriptional regulation of oncogenic pathways within infected cells. The receptor's constitutive activation results in hijacked cellular signaling pathways that promote cell proliferation and survival making US28 a target of interest in therapeutic research for combating HCMV-associated disorders including cardiovascular diseases and cancers. Understanding its structure and function has crucial implications in the development of antiviral strategies aimed at disrupting HCMV signaling and infection mechanisms.

Synonyms

CMV chemokine receptor; G-protein coupled receptor US28